Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort
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- 作者：Aysel Mü ; ezzinlera ; b ; 1 ; Ute Monsa ; 1 ; u.mons@dkfz.de" class="auth_mail" title="E-mail the corresponding author ; Aida Karina Dieffenbacha ; c ; Katja Butterbacha ; Kai-Uwe Sauma ; Matthias Schickd ; Hermann Stammere ; Petra Boukampe ; Bernd Holleczekf ; Christa Stegmaierf ; Hermann Brennera ; b
- 关键词：BMI ; Body mass index ; ESTHER ; Epidemiological Study on the Chances of Prevention ; Early Recognition ; and Optimised Treatment of Chronic Diseases in the Older Population ; kg ; Kilogramme ; LTL ; Leukocyte telomere length ; qPCR ; Quantitative polymerase chain reaction ; TL ; Telomere length ; TRF ; Terminal restriction fragment
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：1-8
- 全文大小：273 K
文摘
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We study the association between obesity and weight changes during adulthood with leukocyte telomere length (LTL).
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Weight gain during adulthood and adiposity may contribute to shorter LTL below age of 60 years.
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We provide supportive evidence for a potential role of obesity in premature ageing as reflected in shorter LTL.
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The cross-sectional associations could however not be shown longitudinally.