Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni

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• 作者：Thiago Almeida Pereira^a ; ^b ; ^c ; Wing-Kin Syn^d ; ^e ; ^f ; Fausto E.L. Pereira^g ; José ; Roberto Lambertucci^b ; William Evan Secor^h ; Anna Mae Diehl^a ; ^{diehl004@mc.duke.edu}
• 关键词：Osteopontin ; Schistosomiasis mansoni ; Liver fibrosis ; Portal hypertension ; Biomarker
• 刊名：International Journal for Parasitology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：13-14
• 页码：829-832
• 全文大小：366 K
• 卷排序：46

文摘

Osteopontin distinguishes severe from mild schistosomiasis in mice and humans. Osteopontin is a novel morbidity biomarker in human and murine schistosomiasis. Failure to modulate osteopontin expression may contribute to severe fibrosis.