Synthesis, structure and antiproliferative activity of chiral polyamines based on a 2-azanorbornane skeleton

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• 作者：Karolina Kamińska^a ; Elżbieta Wojaczyńska^a ; ^{elzbieta.wojaczynska@pwr.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Joanna Wietrzyk^b ; Eliza Turlej^b ; Agnieszka Błażejczyk^b ; Robert Wieczorek^c
• 刊名：Tetrahedron: Asymmetry
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：27
• 期：16
• 页码：753-758
• 全文大小：624 K

文摘

A series of enantiopure 2-azanorbornane-based amines were prepared via a stereoselective aza-Diels–Alder reaction and further modifications of the obtained cycloadduct. In particular, derivatives containing two bicyclic moieties linked by NCCN fragments were synthesized. Two dimeric derivatives exhibited a significant antiproliferative activity against selected cell lines, comparable to cisplatin in certain cases.