One-pot synthesis of polyhydropyrido[1,2-a]indoles and tetracyclic quinazolinones from 2-arylindoles using copper-mediated oxidative tandem reactions
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- 作者：Mitsuaki Yamashita ; yamash@nara.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yukari Nishizono ; Seiya Himekawa ; Akira Iida
- 关键词：Copper ; Oxidation ; Aza-Diels&ndash ; Alder ; Rearrangement ; Indoles
- 刊名：Tetrahedron
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：72
- 期：27-28
- 页码：4123-4131
- 全文大小：787 K
文摘
We developed facile one-pot methods for the transformation of 2-arylindoles to polyhydropyrido[1,2-a]indoles and tetracyclic quinazolinones. The copper-catalyzed oxidation of 2-arylindoles to C-acylimines followed by aza-Diels–Alder reactions or oxidative ring-expansion reactions afforded significant polycyclic heterocycles.