Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using lipase from Candida sp. 99-125

详细信息    查看全文

• 作者：Dong-Hang Yin^a ; Wei Liu^b ; Zhi-Xiang Wang^a ; Xin Huang^a ; Jing Zhang^a ; De-Chun Huang^a ; ^{cpuhdc@cpu.edu.cn}
• 关键词：Aza-Diels&ndash ; Alder reaction ; Lipase ; Catalysis ; Candida sp. 99&ndash ; 125 ; Azabicyclo [2.2.2] octan-5-one
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：153-158
• 全文大小：530 K
• 卷排序：28

文摘

The direct three-component aza-Diels–Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels–Alder reaction catalyzed by lipase from Candida sp. 99–125 provided the products in moderate to excellent yields. Meanwhile, the endo/exo ratio reached up to 88:12.