Copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones with chiral sulfoxide-phosphine ligands

详细信息    查看全文

• 作者：Tingting Yang^a ; Yongling Zhang^b ; Peng Cao^b ; Min Wang^b ; Li Li^c ; Dong Li^a ; ^c ; ^{dongli@mail.hbut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jian Liao^b ; ^{jliao@cib.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Copper catalysis ; Conjugate addition ; Acyclic enones ; Chiral ligand ; Sulfoxide&ndash ; phosphine
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：26 May 2016
• 年：2016
• 卷：72
• 期：21
• 页码：2707-2711
• 全文大小：443 K

文摘

The copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones was achieved with chiral sulfoxide–phosphine (SOP) ligands. This process showed good functional group tolerance and gave the 1, 4-adducts with excellent enantioselectivities (up to 96% ee).