Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation

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• 作者：Ville Varho^a ; ¹ ; ^{viveva@utu.fi} ; Wail Nammas^b ; ¹ ; Tuomas O Kiviniemi^a ; ¹ ; Jussi Sia^c ; ¹ ; Hannu Romppanen^d ; ¹ ; Mikko Pietilä ; ^a ; ¹ ; Juhani K. Airaksinen^a ; ¹ ; Pasi P. Karjalainen^b ; ¹
• 关键词：OCT ; Sampling interval ; Neointimal healing ; Uncovered struts ; Malapposed struts
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：194-200
• 全文大小：1079 K
• 卷排序：227

文摘

Optical coherence tomography (OCT) is widely used for evaluation of healing response to stent implantation. We sought to test the agreement between the 1-mm and 0.6-mm sampling intervals for assessment of the percentage of uncovered and malapposed struts by OCT.MethodsThirty­eight patients presenting with acute coronary syndrome were randomized to receive either a titanium­nitride­oxide­coated stent (n = 19) or an everolimus­eluting stent (n = 19). Neointimal strut coverage and strut apposition were evaluated by OCT at 2­month follow­up. Two independent investigators performed offline OCT image analysis at 1­mm intervals. One investigator repeated the measurements at 0.6­mm intervals and measurements were compared between the two sampling intervals.ResultsAt a median follow­up of 60 [8] days, 694 cross­sections (7603 struts) and 1138 cross­sections (12,331 struts) were analysed at 1­mm and at 0.6­mm intervals, respectively. The median [IQR] percentage of uncovered struts was 3.27% [11.1] versus 3.38% [9.76] (p = 0.001), and the mean (± SD) percentage was 7.69 ± 9.99% versus 6.27 ± 8.14% (p = 0.004), for the 1­mm sampling interval versus the 0.6­mm sampling interval analysis, respectively; the median percentage of malapposed struts was 0.42% [2.04] versus 0.12% [1.63], respectively, (p = 0.003). The intraclass correlation coefficient between the two observers for the percentage of uncovered struts was 0.95.ConclusionsThe OCT-evaluated strut-level measurements of neointimal healing after stent implantation differ significantly between the 1-mm and the 0.6-mm sampling intervals.