In vitro monitoring of amyloid β-peptide oligomerization by Electrospray differential mobility analysis: An alternative tool to evaluate Alzheimer's disease drug candidates
An Electrospray differential mobility analysis method for Aβ1-42 peptide oligomerization was developed. The size and proportion of the oligomers can be determined with good repeatability. We demonstrated the ability of ES-DMA to monitor oligomerization kinetics with or without drug candidates.