TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPK signaling and the RLRs and TLRs on macrophages
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- 作者：Jiang Zhua ; zj972206@163.com" class="auth_mail" title="E-mail the corresponding author ; Guangjie Duana ; gjduan@163.com" class="auth_mail" title="E-mail the corresponding author ; Hu Wangb ; 530310536@qq.com" class="auth_mail" title="E-mail the corresponding author ; Mianfu Caoa ; caomianfu2008@163.com" class="auth_mail" title="E-mail the corresponding author ; Yousheng Liua ; youshengliu88@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMDMs ; Bone marrow-derived macrophages ; CCL-5 ; CC chemokine ligand 5 ; IL-6 ; interleukin 6 ; IL-10 ; interleukin 10 ; IFN-β ; interferon-beta ; LPS ; lipopolysaccharide ; MCP-1 ; monocyte chemoattractant protein-1 ; MDA5 ; melanoma differentiation-associated gene 5 ; NLR ; nucleotide-binding oligomerization domain receptor ; NOD-like receptor ; PAMPs ; pathogen-associated molecular patterns ; poly IC ; polyinosinic-polycytidylic acid ; PRR ; pattern-recognition receptors ; RIG-I ; retinoic acid inducible gene I ; RLR
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：345
- 期：1
- 页码：70-81
- 全文大小：3449 K
文摘
- 5">
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5">TREM-1 on the macrophages is raised in dose- and time-dependent manners by dsRNA.
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TREM-1 ligation can enhance the antivirus inflammation and IFN-β induced by dsRNA.
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TREM-1 activation can enhance MAPKs phosphorylation and expression of RLRs and TLRs.