Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq
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- 作者：Xiaoyu Chena ; 1 ; Ming Yangb ; 1 ; Wenjin Haoc ; Jichun Hanc ; Jun Mac ; Caixia Wangd ; Shiguo Suna ; sunsg@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qiusheng Zhengc ; zqsyt@sohu.com" class="auth_mail" title="E-mail the corresponding author ; johnsonjem@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; RA ; all-trans-retinoic acid ; ISL ; isoliquiritigenin ; DGEs ; differential expressed genes ; DMSO ; dimethyl sulfoxide ; a-MSH ; cAMP-elevating agents such as a melanocyte-stimulating hormone ; MITF ; microphthalmia-associated transcription factor ; GO ; Gene Ontology ; KEGG ; Kyoto Encyclopedia of Genes and Genomes
- 刊名：Gene
- 出版年：2016
- 出版时间：30 October 2016
- 年：2016
- 卷：592
- 期：1
- 页码：86-98
- 全文大小：1419 K
文摘
- 5">
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5">We investigated the transcriptional response of melanoma differentiation process induced by ISL and RA.
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We detected 390 DEGs involves in 201 pathways in ISL treatment and 304 DEGs in 193 pathways in RA treatment, respectively.
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5">Glutathione metabolism, glycolysis / Gluconeogenesis and pentose phosphate pathway were the top three relative pathway perturbed by ISL.
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Mitogen-activated protein kinase (MAPK) signaling pathway was the most important pathway in RA treatment.
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5">We discovered 72 DEGs which probably relatedto melanoma differentiation.