Identification and characterization of the melanoma differentiation - associated gene 5 in sea perch, Lateolabrax japonicus
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- 作者：Peng Jiaa ; 1 ; jiapeng19890219@126.com" class="auth_mail" title="E-mail the corresponding author ; Kuntong Jiaa ; 1 ; jiakuntong@126.com" class="auth_mail" title="E-mail the corresponding author ; Limin Chena ; 2562492896@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yao Lea ; 916107751@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yilin Jina ; 369277368@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jing Zhanga ; zhangj358@mail2.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Limei Zhub ; zhulimeimlz@163.com" class="auth_mail" title="E-mail the corresponding author ; Li Zhangb ; zhangli@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Meisheng Yia ; yimsh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanoma differentiation-associated gene 5 ; Sea perch ; Nervous necrosis virus ; Innate immune
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：161-168
- 全文大小：3011 K
文摘
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The first MDA5 was identified from sea perch.
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5">LjMDA5 transcripts were constitutively expressed in all examined tissues.
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LjMDA5 transcripts were induced greatly in immune and non-immune organs post NNV infection in vivo.
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5">LjMDA5 involved in response to LPS and poly(I:C) stimulation and NNV infection in vitro.
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Silencing of LjMDA5 by RNAi benefited the replication and virus production of RGNNV in vitro.