Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5
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- 作者：Wen-Xin Zhanga ; Er-Wei Zuoa ; Ying Heb ; c ; Dong-Yang Chena ; Xie Longa ; Mei-Juan Chena ; Ting-Ting Lia ; Xiao-Gan Yanga ; Hui-Yan Xua ; Sheng-Sheng Lua ; Ming Zhanga ; Ke-Huan Lua ; ; Yang-Qing Lua ; luy800@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MDA5 ; Promoter ; Chicken ; Innate immunology ; RIG-I-like receptor (RLR) ; Virus
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：1-6
- 全文大小：2109 K
文摘
- 5">
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5">A 2.5 kb chicken MDA5 promoter fragment was cloned and characterized (Accession number 5" class="interref" data-locatorType="ncbi-n" data-locatorKey="KT335979">KT335979).
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The activity of the promoter is extremely low under basal conditions.
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5">Viral (IBDV) and non-viral (IFN-β or poly (I:C) inducers could activate the promoter.
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Gene expression driven by exogenous MDA5 promoter is in accordance with endogenous MDA5.