Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer
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- 作者：Yun-Feng Maa ; 1 ; Yi Renb ; 1 ; Cai-Jun Wua ; 1 ; Xiao-Hui Zhaoa ; Hua Xuc ; Da-Zhou Wuc ; Jiru Xua ; d ; Xiao-Lian Zhange ; Yanhong Jia ; d ; jiyanhong@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-24 ; interleukin-24 ; PBMCs ; peripheral blood mononuclear cells ; MDA ; melanoma differentiation-associated gene ; IFN-γ ; interferon-α ; CTLA4 ; cytotoxic T-lymphocyte-associated protein 4 ; PD1 ; programmed cell death 1 ; TILs ; tumor infiltrating lymphocytes
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：11-20
- 全文大小：2205 K
文摘
- 5">
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5">Administration of IL-24 increased the number of IFN-γ-producing CD8+T cell and especially enhanced the cytotoxicity of CD8+T cells.
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The number and activity of CD8+T cells in TILs were increased, while the number of Treg cells in TILs was decreased greatly by IL-24.
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5">The anti-tumor effect of IL-24 as an immunological regulatory molecule was dependent on CD8+T cells and not CD4+ T cells.
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IL-24 promoted IFN-γ production via the CD8+ T cells and that IL-24 expression correlated inversely with metastasis and clinical tumor stages.