FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
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- 作者：Raú ; l Vivara ; b ; Claudio Humeresb ; Claudia Muñ ; ozb ; Pí ; a Bozab ; Samir Bolivarb ; Felipe Tapiab ; Sergio Lavanderoa ; c ; Mario Chionga ; mchiong@ciq.uchile.cl" class="auth_mail" title="E-mail the corresponding author ; Guillermo Diaz-Arayaa ; b ; gadiaz@ciq.uchile.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFs ; cardiac fibroblasts ; CMFs ; cardiac myofibroblasts ; FBS ; fetal bovine serum ; TGF-β1 ; transforming growth factor-β1 ; α-SMA ; α-smooth muscle actin ; FoxO ; forkhead box type O ; CTGF ; connective tissue growth factor ; p21(WAF1/CIP1) ; p21-cyclin-dependent kinase inhibitor ; p15Ink ; p15-cyclin-dependent kinase inhibitor
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1863
- 期：1
- 页码：128-138
- 全文大小：1580 K
文摘
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TGF-β1 induces the activation of FoxO1 and increases FoxO1 protein level.
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TGF-β1 promotes cardiac fibroblasts differentiation into cardiac myofibroblasts.
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FoxO1 silencing prevents TGF-β1-dependent cardiac fibroblast differentiation.
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FoxO1 overexpression enhances TGF-β1-dependent cardiac fibroblast differentiation.