Fabrication and characterization of platelet-rich plasma scaffolds for tissue engineering applications

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• 作者：Mahmoud Sadeghi-Ataabadi^a ; Zohreh Mostafavi-pour^b ; Zahra Vojdani^a ; Mahsa Sani^a ; Mona Latifi^c ; ^a ; Tahereh Talaei-Khozani^a ; ^{talaeit@sums.ac.ir}
• 关键词：Platelet rich plasma ; Tissue engineering ; CaCl2 ; Mesenchymal stem cell
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：372-380
• 全文大小：1876 K
• 卷排序：71

文摘

Platelet rich plasma (PRP) can be considered as an autologous source for tissue engineering applications. Cell shape, function and differentiation fate are influenced by the mechanical and physical features of the scaffolds. Different CaCl2 concentrations modified some features of the PRP scaffolds including: The scaffolds fabricated by 2.5% CaCl2 had a higher degradation rate and initial cell attachment property. The highest cell viability was on the scaffolds with 2.5% CaCl2 due to higher degradation rate and initial cell attachment. The stress fiber arrangement and as a result, cell phenotype modified by changing the physical properties of the scaffolds. The fiber thickness, orientation, porosity, pore size, branching angle, water content and mechanical strength were the same.