A theoretical validation of the B-matrix spatial distribution approach to diffusion tensor imaging

详细信息    查看全文

• 作者：Karol Borkowski^a ; ^{Karol.Borkowski@fis.agh.edu.pl} ; Krzysztof Kłodowski^a ; Henryk Figiel^a ; Artur Tadeusz Krzyżak^b
• 关键词：MRI ; DTI ; Phantoms ; Diffusion ; Anisotropy
• 刊名：Magnetic Resonance Imaging
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：1-6
• 全文大小：824 K
• 卷排序：36

文摘

The recently presented B-matrix Spatial Distribution (BSD) approach is a calibration technique which derives the actual distribution of the B-matrix in space. It is claimed that taking into account the spatial variability of the B-matrix improves the accuracy of diffusion tensor imaging (DTI). The purpose of this study is to verify this approach theoretically through computer simulations.Assuming three different spatial distributions of the B-matrix, diffusion weighted signals were calculated for the six orientations of a model anisotropic phantom. Subsequently two variants of the BSD calibration were performed for each of the three cases; one with the assumption of high uniformity of the model phantom (uBSD-DTI) and the other taking into account imperfections in phantom structure (BSD-DTI). Several cases of varying degrees of phantom uniformity were analyzed and the distributions of the B-matrix obtained were used for the calculation of the diffusion tensor of a model isotropic phantom. The results were compared with standard diffusion tensor calculation.The simulations confirmed the improvement of accuracy in the determination of the diffusion tensor after the calibration. BSD-DTI improves accuracy independent of both the degree of uniformity of the phantom and the inhomogeneity of the B-matrix. In cases of a relatively good uniformity of the phantom and minor distortions in the spatial distribution of the B-matrix, the uBSD-DTI approach is sufficient.