Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains

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• 作者：Nathaniel D. Kelm^a ; ^b ; Kathryn L. West^a ; ^b ; Robert P. Carson^c ; ^d ; Daniel F. Gochberg^b ; ^e ; Kevin C. Ess^c ; ^d ; Mark D. Does^a ; ^b ; ^e ; ^f ; ^{mark.does@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AC ; anterior commissure ; AD ; axial diffusivity ; AK ; axial kurtosis ; CKO ; conditional knockout ; da ; axon diameter ; Da ; intra-axonal diffusivity ; De ; || ; extra-axonal axial diffusivity ; De ; &perp ; extra-axonal radial diffusivity ; DKI ; diffusion kurtosis imaging ; DTI ; diffusion tensor imaging ; DWI ; diffusion-weighted MRI ; EC ; external capsule ; EM ; transmission electron microscopy ; EPG ; extended phase graph ; FA ; fractional anisotropy ; fa ; histologic axon fraction ; Fa ; axonal water fraction ; fm ; histo
• 刊名：NeuroImage
• 出版年：2016
• 出版时间：1 January 2016
• 年：2016
• 卷：124
• 期：part_PA
• 页码：612-626
• 全文大小：2993 K

文摘

Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex vivo through comparisons to histological measurements and established magnetic resonance imaging (MRI) measures of myelin in two knockout mouse models with varying degrees of hypomyelination. DKI metrics of mean and radial kurtosis were found to be better indicators of myelin content than conventional DTI metrics. The biophysical WMTI model based on the DKI framework reported on axon water fraction with good accuracy in cases with near normal axon density, but did not provide additional specificity to myelination. Overall, DKI provided additional information regarding white matter microstructure compared with DTI, making it an attractive method for future assessments of white matter development and pathology.