Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis
详细信息 查看全文
- 作者：Vanessa Pointa ; Anais Bé ; narouchea ; Julie Zarrilloa ; Alexandre Guyc ; Romain Magnezd ; Laurence Fonsecad ; Brigitt Rauxa ; Julien Leclaireb ; 1 ; Gé ; rard Buonob ; Fré ; dé ; ric Fotiadub ; Thierry Durandc ; Fré ; dé ; ric Carriè ; rea ; Carole Vayssed ; Leslie Couë ; delod ; l.couedelo@iterg.com" class="auth_mail" title="E-mail the corresponding author ; Jean-Franç ; ois Cavaliera ; jfcavalier@imm.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Digestive enzyme ; Enzyme inhibition ; Lipases ; Oxadiazolone ; Gastrointestinal digestion ; Intestinal absorption ; Lymphatic lipids
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：834-848
- 全文大小：2108 K
文摘
- •
Biological evaluation of ten oxadiazolone-core digestive lipase inhibitors.
- •
They discriminate pancreatic (poorly inhibited) from gastric (fully inhibited) lipases.
- •
BemPPOX is the most potent and specific inhibitor of gastric vs. pancreatic lipase.
- •
BemPPOX is able to regulate the whole gastrointestinal lipolysis and fat absorption.