Prolongation of the tibialis anterior CMAP duration in chronic inflammatory demyelinating polyneuropathy

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• 作者：Hiroyuki Nodera^a ; ^b ; ^{hnodera@bidmc.harvard.edu} ; Norman Latov^a ; Bridget Carey^a ; Jennifer Langsdorf^a ; Veronica Bedoya^a ; Svetla Tacheva^a ; Russell L. Chin^a
• 关键词：AH ; abductor hallucis ; CIDP ; chronic inflammatory demyelinating polyneuropathy ; CMAP ; compound muscle action potential ; dCMAP ; distal compound muscle action potential ; EDB ; extensor digitorum brevis ; TA ; tibialis anterior ; TA study ; peroneal motor conduct
• 刊名：Clinical Neurophysiology
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：123
• 期：2
• 页码：393-398
• 全文大小：465 K

文摘

Objective

To assess the duration of the distal compound muscle action potential (dCMAP) recording from the tibialis anterior (TA) as a supportive electrodiagnostic feature in chronic inflammatory demyelinating polyneuropathy (CIDP).

Methods

We performed peroneal motor conduction studies with recording from the TA in 35 CIDP patients, 30 normal controls, and 21 disease controls. The normal cut-off for the TA dCMAP duration was determined to be 14 ms.

Results

Prolonged TA dCMAP durations were detected in 34 % of CIDP patients (12/35) and in 33 % (2/6) of patients in whom only one demyelinating lesion was identified by conventional motor conduction studies. Prolonged TA dCMAP durations were present in 28 % (5/18) of patients with normal duration dCMAPs recorded from the abductor hallucis (AH) and in 42 % (5/12) of patients with normal duration dCMAPs recorded from the extensor digitorum brevis (EDB). In patients with AH or EDB dCMAP amplitudes <1 mV, TA dCMAP durations were prolonged in 28 % and 23 % of patients, respectively.

Conclusions

Determination of TA dCMAP duration appears to be useful for detecting demyelination in CIDP, especially when there is significant coexisting axon loss.

Significance

In patients with potential CIDP and limited electrodiagnostic abnormalities by routine studies, the finding of additional demyelinating findings, such as increased TA dCMAP duration, could allow for improved diagnostic sensitivity.