Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases
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- 作者：Mohamad Adadaa ; Chiara Lubertob ; Daniel Canalsa ; Daniel.Canals@stonybrookmedicine.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：alk-SMase ; alkaline sphingomyelinase ; aSMAse ; acid sphingomyelinase ; ATRA ; all-trans retinoic acid ; BMP ; bismonoacylglycerophosphate ; CAD ; cationic amphiphilic drugs ; CerS ; (dihydro)ceramide synthases ; D609 ; tricyclodecan-9-yl-xanthogenate ; DAG ; diacylglycerol ; IL ; interleukin ; L-aSMAse ; lysosomal-aSMase ; LCD ; lysosomal cell death ; LDLs ; low-density lipoproteins ; LPS ; ly&ndash ; popolysaccharide ; Ma-nSMase ; mitochondrial associated nSMase ; MDR ; multidrug resistant ; NPD ; Niemman&ndash ; Pick disease
- 刊名：Chemistry and Physics of Lipids
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：197
- 期：Complete
- 页码：45-59
- 全文大小：1612 K
文摘
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We summarized the history of the sphingolipid pathway focusing on the sphingomyelin cycle.
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We described the main biologic pathophysiologies involving sphingomyelin synthases and specific sphingomyelinases.
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We numbered, described and named examples of their use of the most used inhibitors for sphingomyelin synthases and sphingomyelinases.