Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway
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- 作者：Nithin B. Boppanaa ; Jeremy S. DeLora ; Eric Van Burenb ; Alicja Bielawskac ; Jacek Bielawskic ; Jason S. Piercec ; Mladen Korbelikd ; Duska Separovica ; b ; dseparovic@wayne.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABT ; ABT-199 ; CERS ; ceramide synthase ; DES ; desaturase ; DNS ; de novo sphingolipid biosynthesis pathway ; FB ; fumonisin B1 ; HNSCC ; head and neck squamous cancer cell carcinoma ; HPR ; fenretinide ; HPV ; human papilloma virus ; MS ; mass spectrometry ; PDT ; photodynamic therapy ; zLEHD-fmk ; zLEHD ; zVAD ; zVAD-fmk
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：191-195
- 全文大小：479 K
文摘
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Dihydroceramide is produced de novo via fumonisin-sensitive ceramide synthase.
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Dihydroceramide then gives rise to ceramide via fenretinide-sensitive desaturase.
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Fenretinide + Foscan-mediated PDT (PDT) enhances dihydroceramide accumulation.
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Fenretinide + PDT enhances fumonisin-sensitive apoptotic cell death.
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Fenretinide + PDT improves long-term tumor cures.