Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
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- 作者：Masayuki Sugimotoa ; b ; Yoichi Shimizuc ; d ; Songji Zhaoe ; Naoyuki Ukone ; Ken-ichi Nishijimaa ; c ; Masato Wakabayashib ; Takeshi Yoshiokab ; Kenichi Higashinob ; Yoshito Numatab ; Tomohiko Okudaf ; Nagara Tamakig ; Hisatoshi Hanamatsuh ; Yasuyuki Igarashih ; Yuji Kugea ; c ; kuge@ric.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：SM ; sphingomyelin ; SMS ; sphingomyelin synthase ; Cer ; ceramide ; CerS ; ceramide synthase ; S1P ; sphingosine 1 phosphate ; LC/ESI-MS/MS ; liquid chromatography/electrospray ionization-tandem mass spectrometry ; VLCFA ; very long-chain fatty acid ; HexCer ; hexosylceramide ; DhCer ; dihydroceramide ; 18F-FDG ; 18F-2-fluoro-2-deoxy-d-glucose ; OGTT ; oral glucose tolerance test ; ITT ; insulin tolerance test ; GSIS ; glucose stimulated-insulin secretion ; HOMA-R ; homeostasis model assessment-insulin resistance ; T2DM
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1861
- 期：8
- 页码：688-702
- 全文大小：2554 K
文摘
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SMS2 deficiency enhances whole body glucose utilization and insulin sensitivity.
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Skeletal muscle contributes to promoting glucose clearance in SMS2 KO mice.
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Skeletal muscle phenotype correlates with SMS2-derived plasma VLCFA-Cer elevation.
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Liver-specific SMS2 deficiency has no impact on whole body glucose metabolism.