Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation
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- 作者：Deepika Awasthia ; Sheela Nagarkotia ; Amit Kumara ; Megha Dubeya ; Abhishek Kumar Singha ; Priya Pathaka ; Tulika Chandrab ; Manoj Kumar Barthwala ; Madhu Dikshita ; madhu_dikshit@cdri.res.in" class="auth_mail" title="E-mail the corresponding author ; madhudikshit@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-HNE ; 4-hydroxynonenal ; ABAH ; 4-aminobenzoic acid hydrazide ; ApoB ; Aproprotein B 100 ; BSA ; bovine serum albumin ; CD ; cluster of differentiation ; DAPI ; 4ʹ ; 6-diamidino-2-phenylindole ; DCF-DA ; 2 ; 7-dichlorofluorescein diacetate ; DFP ; diisopropyl fluorophosphates ; DHE ; dihydroethidium ; DPI ; diphenyleneiodonium chloride ; HDL ; high density lipoprotein ; IRAKs ; interleukin-1 receptor associated kinase ; IL-1β ; interleukin-1 beta ; IL-8 ; Interleukin 8 ; LDL ; low density lipoprotein ; LPC ; lysophosphatidylcho
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：190-203
- 全文大小：3729 K
文摘
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OxLDL mediated the release of neutrophil extracellular traps (NETs) from human PMNs.
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OxLDL induced ROS generation and NETs formation was dependent on NADPH oxidase.
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TLR-PKC-IRAK-MAPK pathway was found to be involved in oxLDL induced NETs formation.
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Oxidized phospholipids component of oxLDL was crucial and most potent NETs inducer.