Synthesis and pharmacological evaluation of new arylpiperazines. 3-{4-[4-(3-chlorophenyl)-1-piperazinyl]butyl}-quinazolidin-4-one — a dual serotonin 5-HT_1A/5-HT_2A receptor

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• 作者：Bojarski ; Andrzej J. ; Kowalski ; Piotr ; Kowalska ; Teresa ; Duszynska ; Beata ; Charakchieva-Minol ; Sijka ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2002
• 出版时间：December, 2002
• 年：2002
• 卷：10
• 期：1
• 页码：3817-3827
• 全文大小：176 K

文摘

On the basis of systematic studies on the structure–activity relationships in arylpiperazine group of serotonin ligands, 12 new derivatives containing quinazolidin-4(3H)-one (1–4), 2-phenyl-2,3-dihydrophthalazine-1,4-dione (5–8) or 1-phenyl-1,2-dihydropyridazine-3,6-dione (9–12) fragments were synthesized. The majority of the tested compounds (2, 4, 7, 8 and 10–12) showed a high affinity for 5-HT_1A receptors (K_i