Site-selective multicomponent synthesis of densely substituted 2-oxo dihydropyrroles catalyzed by clean, reusable, and heterogeneous TiO₂ nanopowder

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• 作者：Sunil Rana^a ; Mike Brown^b ; Arghya Dutta^c ; Asim Bhaumik^c ; Chhanda Mukhopadhyay^a ; ^{cmukhop@yahoo.co.in}
• 关键词：Multicomponent synthesis ; 2-Oxo dihydropyrroles ; Site selectivity ; TiO2 nanopowder
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：13 March, 2013
• 年：2013
• 卷：54
• 期：11
• 页码：1371-1379
• 全文大小：1367 K

文摘

An efficient method for the synthesis of densely substituted 2-oxo dihydropyrroles has been demonstrated by clean, reusable, and heterogeneous catalyst titanium dioxide (TiO₂) nanopowder by the four component coupling reaction of dialkyl but-2-ynedioate, two different amines, and an aldehyde. The reaction is site-selective with respect to aromatic and aliphatic amines. Environmentally benign reaction procedure, excellent yields, tolerance of varieties of functionalities in the reactants, a wide variety of products and reusability of the catalyst make the methodology highly beneficial for the synthesis of polyfunctional dihydropyrroles.