Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward
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- 作者：Marí ; a F. Coronela ; b ; Florencia Labombardac ; d ; Susana L. Gonzá ; leza ; d ; sugnzlz@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALLO ; Allopregnanolone ; GABAA ; γ-aminobutyric acid type A ; NMDA ; N-methyl-d-aspartate ; SP ; substance P ; CGPR ; calcitonin gene-related peptide ; KOR ; kappa opioid receptor ; DOR ; delta opioid receptor ; MOR ; mu opioid receptor ; DHEA ; dehydroepiandrosterone ; DHEAS ; dehydroepiandrosterone sulfate ; DHT ; 5α-dihydrotestosterone ; 3α-diol ; 5α-androstane-3α ; 17β-diol ; THP ; 3α ; 5α-tetrahydroprogesterone ; P0 ; myelin protein zero ; PMP22 ; peripheral myelin protein 22 ; MAL ; myelin and lymphocyte protein ; PKCγ ; gam
- 刊名：Steroids
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：77-87
- 全文大小：981 K
文摘
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Neuroactive steroids are involved in the modulation of pain sensitivity.
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Neuroactive steroids also modulate pain messages in neuropathic conditions.
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Progesterone and Allopregnanolone administration might counteract chronic pain.
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Neurosteroids locally produced in the spinal cord also reduce neuropathic pain.
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Promoting neurosteroidogenesis represent a useful tool to alleviate neuropathic pain.