刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:January 2017
年:2017
卷:165
期:part_PB
页码:182-189
全文大小:1422 K
卷排序:165
文摘
Melatonin suppresses catecholamine synthesis by suppressing the MT1-cAMP pathway in adrenomedullary cells. Melatonin enhances the inhibitory effect of BMP-4 on catecholamine synthesis by amplifying Smad signaling. Melatonin augments glucocorticoid-induced catecholamine synthesis by upregulating GR expression. Melatonin, BMP-4 and glucocorticoid mutually play a modulatory role in catecholamine biosynthesis.