1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport
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- 作者：Y.-X. Guoa ; b ; &dagger ; ; L.-Y. Hea ; b ; &dagger ; ; M. Zhanga ; b ; F. Wanga ; b ; F. Liua ; b ; W.-X. Penga ; pwx.csu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：1 ; 25(OH)2D3 ; 1 ; 25-dihydroxyvitamin D3 ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; amyloid-β ; BBB ; blood&ndash ; brain barrier ; bEnd.3 ; mouse brain microvascular endothelial cell lines ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; ELISA ; enzyme-linked immunosorbent assay ; FBS ; fetal bovine serum ; HepG2 ; human hepatoblastoma cell lines ; HRP ; horseradish peroxidase ; LRP1 ; low-density lipoprotein receptor-related protein 1 ; RAGE ; receptor for advanced glycation end products ; RAP ; receptor-associated
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：28-38
- 全文大小：1336 K
文摘
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1,25(OH)2D3 enhanced Aβ1–40 brain-to-blood efflux by upregulating LRP1 expression in bEnd.3 cells under hypoxia and mice.
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1,25(OH)2D3 reduced Aβ1–40 blood-to-brain influx by downregulating RAGE expression in bEnd.3 cells under hypoxia.
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1,25(OH)2D3 increased Aβ1–40 peripheral uptake by upregulating LRP1 expression in HepG2 cells.
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1,25(OH)2D3 upregulated VDR expression in mice hippocampus, bEnd.3 cells under hypoxia and HepG2 cells.