Influence of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep
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- 作者：M.R. Wilkensa ; Mirja.Wilkens@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author ; L.M. Maté ; b ; N. Schnepela ; S. Klingera ; A.S. Muscher-Bansea ; M. Ballentb ; G. Virkelb ; A.L. Lifschitzb
- 关键词：P-gp ; MDR1 ; ABCB1 ; P-glycoprotein ; CYP3A4 ; cytochrome P450 3A ; VDR ; vitamin D receptor ; PXR ; pregnane X receptor ; RXR ; αretinoid X receptor ; BW ; body weight ; 25-OHD3 ; 25-hydroxyvitamin D3 ; 1 ; 25-(OH)2D3 ; 1 ; 25-dihydroxyvitamin D3
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：271-276
- 全文大小：761 K
文摘
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In contrast to rodents no induction of renal P-glycoprotein by 1,25-dihydroxyvitamin D in sheep.
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Reduction of ruminal, jejunal and hepatic P-glycoprotein expression by 25-hydroxyvitamin D.
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Induction of cytochrome P450 3A only with 1,25-dihydroxyvitamin D treatment.
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Drug–drug interactions caused by vitamin D metabolites cannot be excluded.