Induction of cryptic bioactive 2,5-diketopiperazines in fungus Penicillium sp. DT-F29 by microbial co-culture

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• 作者：Liyan Yu^a ; Wanjing Ding^a ; Qianqian Wang^a ; Zhongjun Ma^a ; ^{mazj1976@163.com} ; Xiaowu Xu^b ; ; Xiaofeng Zhao^b ; ; Zhe Chen^c ;
• 关键词：Microbial co-culture ; Marine fungus ; 2 ; 5-Diketopiperazines ; BRD4 inhibitor
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：16 February 2017
• 年：2017
• 卷：73
• 期：7
• 页码：907-914
• 全文大小：959 K
• 卷排序：73

文摘

Ten new and 13 known prenylated 2,5-diketopiperazines (2,5-DKPs) were identified from co-culture of Penicillium sp. DT-F29 with Bacillus sp. B31. The constitutions and relative configurations of new compounds were established by 1D and 2D NMR spectroscopic data analysis. The isolated 2,5-DKPs in bioactivity test showed bromodomain-containing protein 4 (BRD4) inhibitory activities, and compound 14, with IC50 values of 6.54 μM, was potential for BRD4 inhibitor discovery.