Oscillatory shear stress, flow-mediated dilatation, and circulating microparticles at sea level and high altitude

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• 作者：Joshua C. Tremblay^a ; ^{15jct1@queensu.ca} ; Stephen R. Thom^b ; Ming Yang^b ; Philip N. Ainslie^a
• 关键词：Endothelium ; Vascular ; Cell-derived microparticles ; Haemodynamics ; Hypoxia ; Vasodilatation
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：115-122
• 全文大小：764 K
• 卷排序：256

文摘

Circulating microparticles are increased at high altitude compared to sea level. Briefly imposing oscillatory shear impairs endothelial function at high altitude. Endothelial function is worsened by endothelial injury at high altitude. Brief exposure to high altitude invokes a vulnerable endothelial phenotype.