Genotyping of human papillomavirus in triaging of low-grade cervical cytology

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• 作者：Anna Sö ; derlund-Strand ; PhD^a ; Carina Eklund ; BSc^a ; Levent Kemetli^b ; Lena Grillner ; MD ; PhD^c ; Sven Tö ; rnberg ; MD ; PhD^b ; Joakim Dillner ; MD ; PhD^a ; ^c ; ^d ; Lena Dillner ; MD ; PhD^a
• 关键词：human papillomavirus genotyping ; low-grade cervical cytology ; triaging
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：August, 2011
• 年：2011
• 卷：205
• 期：2
• 页码：145.e1-145.e6
• 全文大小：220 K

文摘

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Objective

The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse).

Study Design

A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated.

Results

HPV 16 was detected in 57 % of cases with CIN III or worse but only among 24 % of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77 % of CIN III or worse, with 36 % of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse.

Conclusion

Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.