G protein-coupled receptor dimerisation: Molecular basis and relevance to function

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• 作者：Graeme Milligan
• 关键词：G protein-coupled receptor ; Dimerisation ; Signal transduction
• 刊名：Biochimica et Biophysica Acta (BBA)/Biomembranes
• 出版年：2007
• 出版时间：April 2007
• 年：2007
• 卷：1768
• 期：4
• 页码：825-835
• 全文大小：227 K

文摘

The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order oligomeric complexes. Key roles for receptor homo-dimerisation include effective quality control of protein folding prior to plasma membrane delivery and interactions with hetero-trimeric G proteins. Growing evidence has also indicated the potential for many co-expressed G protein-coupled receptors to form hetero-dimers/oligomers. The relevance of this to physiology and function is only beginning to be unravelled but may offer great potential for more selective therapeutic intervention.