Selectivity in the oligomerisation of G protein-coupled receptors

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• 作者：Milligan ; Graeme ; Lopez-Gimenez ; Juan ; Wilson ; Shirley ; Carrillo ; Juan J.
• 关键词：GPCR ; G protein-coupled receptor ; G protein-coupled receptor ; Dimerisation ; Signal transduction
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2004
• 出版时间：June, 2004
• 年：2004
• 卷：15
• 期：3
• 页码：263-268
• 全文大小：82.2 K

文摘

G protein-coupled receptors can exist as dimers and/or higher order oligomers. Such quaternary structure appears central to their plasma membrane delivery and, potentially, to function. Recent evidence that these receptors can form hetero- as well as homo-dimers/oligomers has significant implications for pharmacology and pathophysiology. Knowledge of the basis and selectivity of GPCR hetero-dimerisation is thus vital. Current understanding of these areas is reviewed.