Direct acylation of aryl amines using dimethylformamide and dimethylacetamide as the acyl resources

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• 作者：Qing Zhang ; ^{mmczhang@yeah.net" class="auth_mail" title="E-mail the corresponding author} ; Cui Chen
• 关键词：Acylation reaction ; Dimethylformamide ; Dimethylacetamide ; Aryl amines
• 刊名：Journal of Saudi Chemical Society
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：20
• 期：1
• 页码：114-119
• 全文大小：3481 K

文摘

The treatment of aryl amines with dimethylformamide (DMF) and dimethylacetamide (DMA) in the presence of hydrochloric acid brings about efficient N-acylation to give the corresponding aryl formamides and aryl acetamides in acceptable to excellent yields. This method is simple, general, and practical for the rapid construction of aryl formamide and aryl acetamide derivatives.