Betaine chemistry, roles, and potential use in liver disease
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- 作者：Christopher R. Daya ; Stephen A. Kempsonb ; skempson@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALD ; alcoholic liver disease ; AMPK ; AMP-activated protein kinase ; BGT1 ; Na+/Cl&minus ; -dependent betaine&ndash ; GABA transporter ; BHMT ; betaine&ndash ; homocysteine methyltransferase ; DMG ; dimethylglycine ; NAFLD ; non-alcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; OCTN2 ; organic cation/carnitine transporter ; SAH ; S-adenosylhomocysteine ; SAM ; S-adenosylmethionine ; SIT1 ; Na+-dependent imino acid transporter ; SNAT ; Na+-dependent neutral amino acid transporter
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1098-1106
- 全文大小：1159 K
文摘
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Betaine has several unique roles in animal and human health.
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Most abundant in liver and is a methyl donor in one-carbon metabolism.
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Betaine is used clinically to decrease homocysteine in plasma.
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Alcoholic liver and non-alcoholic fatty liver are worldwide diseases.
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Betaine alleviates most disturbances in rodent models of these diseases.