Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
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- 作者：Benjamin A. Kandela ; b ; Maria Thomasa ; b ; Stefan Wintera ; b ; Georg Dammc ; Daniel Seehoferc ; Oliver Burka ; b ; Matthias Schwaba ; b ; d ; Ulrich M. Zangera ; b ; uli.zanger@ikp-stuttgart.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADME ; absorption ; distribution ; metabolism ; excretion ; CAR ; constitutive androstane receptor (NR1I3) ; CITCO ; 6-(4-Chlorophenyl)imidazo[2 ; 1-b][1 ; 3]thiazole-5-carbaldehyde O-(3 ; 4-dichlorobenzyl)oxime ; CYP ; cytochrome P450 ; DMET ; drug metabolism and transport ; PHH ; primary human hepatocytes ; PPARα ; peroxisome proliferator-activated receptor alpha (NR1C1) ; PXR ; pregnane X receptor (NR1I2) ; WY14 ; 643 ; [[4-chloro-6-[(2 ; 3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1859
- 期：9
- 页码：1218-1227
- 全文大小：1309 K
文摘
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Microarray analysis of primary human hepatocytes of six donors treated with prototype inducers
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Global comparison of induced transcriptomes of CAR (CITCO), PXR (Rifampicin), PPARAα (WY14,643)
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Overlapping sets of coregulated and distinctly regulated and novel responsive genes and pathways
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20">Drug metabolism and transport genes coordinately up- or downregulated
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25">Lipid metabolism and energy homeostasis genes counterregulated by PPARα and PXR