Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response
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- 作者：Li-Li Gua ; Xin-Yue Zhangb ; Wen-Min Xinga ; Jia-Dong Xua ; Hong Lua ; luhong03@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; andrographolide ; ASB ; andrographolide sodium bisulfite ; BCA ; bicinchoninic acid ; CHOP ; C/EBP homologous protein ; ER ; endoplasmic reticulum ; GRP78 ; glucose-regulated protein 78 ; HRP ; horseradish peroxidase ; IL-6 ; Interleukin-6 ; KIM-1 ; kidney injury molecule-1 ; MDA ; maleic dialdehyde ; MTT ; 3-[4 ; 5-dimethylthiazol-2yl]-2 ; 5-diphenyl tetrazolium bromide ; ROS ; reactive oxygen species ; SOD ; superoxide dismutase ; TNF-α ; tumor necrosis factor-α ; URP ; unfolded protein response
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：45
- 期：Complete
- 页码：257-264
- 全文大小：2517 K
文摘
- 5">
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5">Andrographolide inhibited HK-2 cells proliferation and induced apoptosis.
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The mechanism is associated with activation of oxidative stress and ER stress.
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5">Andrographolide decreased the production of inflammation cytokines after prolonging the time of drug action.