Resveratrol attenuates MPP⁺-induced mitochondrial dysfunction and cell apoptosis via AKT/GSK-3β pathway in SN4741 cells

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• 作者：Weijun Zeng^a ; ¹ ; Wei Zhang^b ; ^c ; ¹ ; Fangfang Lu^a ; Li Gao^a ; Guodong Gao^a ; ^{gaogd1954@163.com}
• 关键词：Res ; Resveratrol ; MPP+ ; 1-methyl-4-phenylpyridinium ; PD ; Parkinson&rsquo ; s disease ; GSK-3 ; Glycogen synthase kinase-3 ; GSK-3β ; Glycogen synthase kinase-3 beta ; AKT ; Protein kinase B ; MMP ; Mitochondrial membrane potential ; PI3K ; Phosphatidylinositol 3-kinase ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; MTT ; 3-(4 ; 5-dimethylthiazol-2yl)-2 ; 5-diphenyltetrazolium bromide
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：50-56
• 全文大小：1900 K
• 卷排序：637

文摘

We identify that resveratrol attenuates MPP+-induced mitochondrial dysfunction and cell apoptosis in SN4741 cells. We confirm the underlying mechanism of this protection at least partially through the AKT/GSK-3β pathway.