Characterisation and cytotoxic screening of metal oxide nanoparticles putative of interest to oral healthcare formulations in non-keratinised human oral mucosa cells in vitro
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- 作者：M. Besta ; M.Best2@brighton.ac.uk" class="auth_mail" title="E-mail the corresponding author ; G. Phillipsa ; C. Fowlerb ; J. Rowlandb ; J. Elsoma
- 关键词：DLS ; dynamic light scattering ; LDH ; lactate dehydrogenase ; MTT ; dimethylthiazolyl-diphenyl-tetrazolium-bromide ; NTA ; nanoparticle tracking analysis ; PRF ; Phenol red-free ; PBS ; phosphate-buffered saline ; SiO2 ; silica ; TiO2 ; titanium dioxide ; SD ; standard deviation ; SEM ; scanning electron microscopy ; ZnO ; zinc oxide
- 刊名：Toxicology in Vitro
- 出版年：2015
- 出版时间：25 December 2015
- 年：2015
- 卷：30
- 期：1
- 页码：402-411
- 全文大小：1752 K
文摘
- 5">
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200">Nanoparticle cytotoxicity of interest for future oral healthcare formulations.
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205">Nanoparticles characterised using SEM and DLS, in the absence of stabilisers.
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210">H376 oral epithelial cell model was used for the first time in preliminary screening.
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215">Hydroxyapatite, SiO2 and TiO2 nanoparticles were well tolerated in the model.
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220">ZnO significantly more cytotoxic than other materials, but were not nano-dependent.