Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats
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- 作者：Mahendra Ram ; Vishakha Singh ; Sanjay Kumawat ; Vinay Kant ; Surendra Kumar Tandan ; Dinesh Kumar ; dineshks17@gmail.com" class="auth_mail" title="E-mail the corresponding author ; dineshks17@ivri.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bilirubin ; Cytokines ; Growth factors ; Angiogenesis ; Diabetic rats ; Wound healing
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：137-149
- 全文大小：2455 K
文摘
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The percent wound closer was significantly higher in bilirubin-treated rats.
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mRNA and protein levels of HIF-1α, VEGF, SDF-1α, TGF-β1, IL-10 were significantly higher in bilirubin-treated rats.
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TNF-α, MMP-9 and IL-1β were mRNA were significantly down regulated in bilirubin-treated rats.
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The collagen deposition and formation of blood vessels were greater in bilirubin-treated rats.
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Bilirubin markedly facilitated cutaneous wound healing in diabetic rats.