Highly chemoselective hydrogenation of active benzaldehydes to benzyl alcohols catalyzed by bimetallic nanoparticles

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• 作者：Chulong Liu ; Hailin Bao ; Dingsheng Wang ; Xinyan Wang ; Yadong Li ; Yuefei Hu
• 关键词：Chemoselectivity ; Catalytic hydrogenation ; Active benzaldehydes ; Benzyl alcohols ; Bimetallic nanoparticles
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：18 November 2015
• 年：2015
• 卷：56
• 期：46
• 页码：6460-6462
• 全文大小：707 K

文摘

By using novel Pd/Ni bimetallic nanoparticles as a catalyst, the active benzaldehydes were hydrogenated to the corresponding benzyl alcohols as unique products in practical quantitative yields. The undesired catalytic hydrogenolysis of the benzyl alcohol was inhibited completely. By using this hydrogenation as a key step, the total synthesis of the natural product gastrodin was achieved with less total steps and a higher total yield.