Early Changes of Peripheral Blood Lymphocyte Subpopulations in Patients with Occupational 2,4-dinitrophenol Poisoning

详细信息    查看全文

• 作者：Jiu Kun JIANG^aAuthor Vitae ; Wen FANG^a ; Lin Hui GU^b ; Yuan Qiang LU^a ; ^{luyuanqiang201@hotmail.com} ; ^{luyuanqiang@zju.edu.cn}
• 刊名：Biomedical and Environmental Sciences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：29
• 期：12
• 页码：909-914
• 全文大小：805 K
• 卷排序：29

文摘

2,4-dinitrophenol (DNP), an organic compound which frequently used in industry, is considered to have high toxicity. This study aimed to investigate the early changes of lymphocyte subpopulations in patients with occupational 2,4-DNP poisoning. Totally 9 patients with acute occupational 2,4-DNP poisoning and 30 healthy volunteers as control were enrolled. The patients received immediately comprehensive supportive treatments, including large-dose glucocorticoid and repeated hemoperfusion (HP). The ratio of CD4+/CD8+ T cells were significantly higher in patients upon admission compared to healthy controls (P < 0.01); however, counts of total lymphocytes, CD3+, CD3+CD4+, CD3+CD8+, B (CD19+), and natural killer (NK) cells (CD16+CD56+) were significantly reduced (all P < 0.001). The NK cell count was negatively correlated with initial plasma 2,4-DNP concentration (r = −0.750, P = 0.026). Thus, acute occupational 2,4-DNP poisoning was accompanied by immediate complex immune cell reactions, especially NK cells might play important role in severe 2,4-DNP poisoning.