Synthesis, characterization, and antitumor activity of three ternary dinuclear copper (II) complexes with a reduced Schiff base ligand and diimine coligands in vitro and in vivo
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- 作者：Lei Jiaa ; Jun Xua ; xjjl@hpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaolei Zhaoa ; Shanshan Shenc ; Tao Zhoua ; Zhouqing Xua ; zhqxu@hpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Taofeng Zhub ; taofengzhu@foxmail.com" class="auth_mail" title="E-mail the corresponding author ; Ruhua Chenb ; Tieliang Mab ; Jing Xieb ; Kun Donga ; Jiancui Huanga
- 关键词：Ternary dinuclear copper(II) complexes ; Schiff base ligand ; Diimine coligands ; Antitumor effects
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：107-119
- 全文大小：2864 K
文摘
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The biological activity of three ternary copper (II) complexes were investigated.
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The three complexes can cause DNA damage.
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Cell apoptosis was detected by flow cytometry and Western blotting.
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All the complexes can effectively induce apoptosis of the human tumor cells.