The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex

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• 作者：Keith S. Wong¹ ; ^&dagger ; ; Vaibhav Bhandari¹ ; ^&dagger ; ; Sarath Chandra Janga² ; Walid A. Houry¹ ; ³ ; ^{walid.houry@utoronto.ca}
• 关键词：VWA ; von Willebrand factor A ; RavA ; regulatory ATPase variant A ; ViaA ; VWA interacting with AAA  ; + ATPase ; LdcI ; lysine decarboxylase ; Nuo complex ; NADH ; ubiquinone oxidoreductase I ; Frd ; fumarate reductase ; WT ; wild-type ; FAD ; flavin adenine dinucleotide ; EMSA ; electromobility shift assay ; KO ; knockout ; ORF ; open reading frame ; SPA ; sequential peptide affinity ; TEV ; tobacco etch virus ; MW ; molecular weight ; CTV ; C-terminal domain of ViaA ; NTV ; N-terminal domain of ViaA ; SEC ; size-exclusion c
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：429
• 期：2
• 页码：324-344
• 全文大小：1146 K
• 卷排序：429

文摘

RavA-ViaA form a chaperone-like complex interacting with respiratory chains. RavA-ViaA are induced under oxygen-limiting conditions. RavA-ViaA interact with the flavin-containing subunit of fumarate reductase. RavA-ViaA modulate the activity of the fumarate reductase complex.