Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi
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- 作者：Paulo André ; Teixeira de Moraes Gomes
- 关键词：Chagas disease ; Trypanosoma cruzi ; Thiazole ; Hydrazone ; Phthalimide
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：46-57
- 全文大小：1663 K
文摘
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- <p id="p0010">The anti-T. cruzi activity of 26 phthalimido-thiazoles were evaluated.p>
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- <p id="p0015">Five compounds presented better trypanocidal activity than Benznidazole.p>
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- <p id="p0020">Compound 6j was 26-fold more selective than Benznidazole.p>
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- <p id="p0025">The structural upgrade planned present positive effects on trypanocidal activity.p>