Triterpenoids and an alkamide from Ganoderma tsugae

详细信息    查看全文

• 作者：Kai-Wei Lin^a ; Dravidum Maitraie^a ; A-Mei Huang^b ; Jih-Pyang Wang^c ; Chun-Nan Lin^d ; ^e ; ^{lincna@cc.kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lanostanoid ; Seco-lanostanoid ; Ganoderma tsugae ; Antioxidant ; Anti-inflammatory ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：108
• 期：Complete
• 页码：73-80
• 全文大小：885 K

文摘

Ganoderma tsugae is a medicinal mushroom. In a continual study on the bioactive constituents of this fungus, a new lanostanoid, 3β-acetoxy-16α-hydroxy-24ξ-methyl-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid F (1) and a novel palmitamide, N-(3′α,4′β-dihydroxy-2′β-(hydroxymethyl)-1′β-(cyclobutyl)palmitamide (2) were isolated and characterized from the fruit bodies of G. tsugae, and three novel seco-lanostanoids, 3,4-seco-8α,9α-epoxy-5α-lanosta-21-oic acid 3,4 lactone (5), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid-3-methyl ester (6), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid (7), and a known compound, 3-oxo-5α-lanosta-8-en-21-oic acid (4) were prepared from 3. The structures of new compounds, 1, 2, 5–7 were determined by spectroscopic methods. Compounds 1 and 4 showed inhibitory effects on xanthine oxidase (XO) with an IC₅₀ values of 313.3 ± 80.0 and 43.9 ± 29.9 μM, respectively when 7 exhibited potent inhibitory effect on superoxide anion generation in rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) with an IC₅₀ values of 1.3 ± 0.2 μM. Compounds 4–7 showed weak cytotoxic activities against PC3 cells. These results indicated that 4 and 7 may be used as cancer chemopreventive agents.