刊名:Biochimica et Biophysica Acta (BBA) - Biomembranes
出版年:2017
出版时间:March 2017
年:2017
卷:1859
期:3
页码:493-506
全文大小:2807 K
卷排序:1859
文摘
Second voltage-sensing domain of human Nav1.4 channel (VSD-II) was studied by NMR VSD-II aggregates in environments containing phospholipids (bicelles, nanodiscs) Secondary structure of VSD-II in LPPG micelles is similar to bacterial Na+ channels μs-ms motions were observed in the regions of expected interhelical contacts of VSD ‘Divide and conquer’ approach is applicable for structural studies of Na+ channels