Cell death mechanistic study of photodynamic therapy against breast cancer cells utilizing liposomal delivery of 5,10,15,20-tetrakis(benzo[b]thiophene) porphyrin
文摘
Hydrophobic BTP induced photodynamic effects against MCF-7 breast cancer cells. The lipid composition of the liposomes affected the subcellular localization of BTP. DOPC-BTP and DOPE-BTP were localized in the nucleus. M1-BTP and M2-BTP were localized mainly in the ER and partially in the nucleus. The cancer cell death mechanism depended on the subcellular localization.