Design and synthesis of enantiomeric (R)- and (S)-copper(II) and diorganotin(IV)-based antitumor agents: Their in vitro DNA binding profile, cleavage efficiency and cytotoxicity studies
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- 作者：Farukh Arjmand ; farukh_arjmand@yahoo.co.in" class="auth_mail ; Mohd. Muddassir ; Imtiyaz Yousuf
- 关键词：Cu(II) and diorganotin(IV) enantiomeric complexes ; Preliminary DNA binding studies ; Cleavage activity ; Cytotoxicity activity ; SRB assay
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：5 July 2014
- 年：2014
- 卷：136
- 期：Complete
- 页码：62-71
- 全文大小：1075 K
文摘
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Synthesis of enantiomeric R/S-complexes 1–4 from reduced Schiff bases, L and L′.
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In vitro DNA binding studies of ligands L and L′ and their complexes (R/S)-1–4.
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1 (S-enantiomer) exhibited highest binding propensity towards CT DNA.
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1 (S-enantiomer) displayed efficient pBR322 DNA cleavage activity.
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In vitro cytotoxicity of L, L′ and complexes 1–4 by SRB was also evaluated.